"Magnesium Benefits, Deficiency Signs & Top Food Sources You Need to Know"

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Like the liver, kidneys play a vital role in maintaining the body's normal state (homeostasis). There are two kidneys in the human body. The nephron is the basic functional unit of the kidney. Each kidney has about a million nephrons. Each nephron has two main parts.
Each nephron functions independently to produce urine. This means that over 99 percent of the filtered water, all the glucose and vitamin C, almost all amino acids, sodium and other substances are returned to the blood. But if the intake of salt exceeds the body's needs the excess is excreted and extra water is needed to excrete it.
The kidneys help to regulate the internal harmony by performing the following functions:
1. Filtration: The kidneys are the filters through which all dissolved substances pass and selectively absorb those to be retained. Figure 30.1 depicts the urinary system. The end products of protein metabolism (urea, creatinine, uric acid and urates) are removed from blood by filtration to be discarded in urine. Excess of chloride, potassium, sodium and hydrogen ions are also filtered out from the blood. By being selective filters, kidneys try to maintain a constant blood composition and volume.
2. Maintenance of Fluid, Electrolyte and Acid-base Balance. Ions from the blood are secreted into the urine to maintain acid-base balance In this process they monitor the composition and volume of blood and other body fluids. Kidneys maintain fluid electrolyte and acid-base balance as they carry out selective filtration..
3. Excretion: The kidneys excrete dissolved unwanted substances filtered out of the blood as urine.
4. The kidneys help regulate the blood pressure.
5. Kidneys produce erythropoietin (a hormone), which stimulates maturation of red blood cells in the bone marrow.
6. The conversion of vitamin D to its most active form calcitriol occurs in the kidneys. Activated vitamin D regulates the absorption of calcium and phosphorus and thus helps: regulate calcium and phosphorus levels in the blood.
When kidney function is disturbed due to disease or trauma, all the above functions are affected adversely.
Several ailments may cause kidney disorders. These include infection, degenerative changes, chronic diseases (e.g., diabetes mellitus, cardiovascular disorders such as atherosclerosis, hypertension), medications, toxic metal consumption, cysts, renal stones or trauma. Surgery, burns and poisons are some traumas, which may cause kidney damage.
Obesity increases the risk of renal disease. Habitual intake of high protein diet may increase the work of kidneys and cause damage. Reducing weight, decreasing protein intake to normal level can decrease the risk of kidney disease.
The most common cause of renal failure is diabetic nephropathy. Some antibiotics and pain medications may cause renal disease. The normal function of the nephrons, the working unit of kidneys. may be upset by the above ailments..
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